24 Top innovators

Call them innovators, entrepreneurs, or good old-fashioned trouble-makers. These 24 disrupters have gone up against the odds as they've rattled old industries and tried to create new ones.

Nick Grouf
Nick Grouf
Spot Runner
TV advertising once required horribly expensive Madison Avenue ad agencies. That was before Nick Grouf figured out that some ads don't require a high-maintenance artiste and a three-martini lunch. Enter Spot Runner, a web-driven do-it-yourself ad-production company that allows even the most modest of businesses to whip up professional TV ads, buy airtime, and schedule them to run across the nation. This is a third at-bat for Grouf, who with partner David Waxman also founded PeoplePC and Firefly Networks. It's no surprise they have already snapped up $60 million in funding. --O.R.

Mark Gorton

Glueckman and Kantor

Hjalmar Winbladh

Craig Venter

Sunil Shaunak

Diane Greene

Nick Grouf

Caleb Chung

Stoppelman and Simmons

Glenn Kelman

Dan Olschwang

David Della Terza

Jack Memishian

Martin Eberhard

Vinod Khosla
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