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11. Goldman Sachs Group
Fortune 500 rank: 20
2007 profit: $11.6 billion

The perennial Wall Street titan remarkably increased profit 22% during the year by avoiding mortgage-related losses - something some of its closest competitors failed to do.

Goldman, an investment bank and the world's biggest securities firm, said it shorted the subprime market for much of the year.

NEXT: Johnson & Johnson

Last updated April 24 2008: 11:07 AM ET