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12. Johnson & Johnson
Fortune 500 rank: 35
2007 profit: $10.58 billion

The health care giant, which makes products from Band-Aids to pharmaceuticals, saw its 2007 profit drop 4%.

Safety concerns over two key products - the artery device Cypher and anemia drug Procrit - contributed to the earnings decline.

Sales rose 15%, largely from its 2006 acquisition of Pfizer's consumer health business.

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Last updated April 24 2008: 11:07 AM ET