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15. Altria Group
Fortune 500 rank: 61
2007 profit: $9.79 billion

Sales at the tobacco holding company dropped 46% during the year after its 2006 spinoff of Kraft Foods. Profits followed suit, declining 19% on slumping U.S. cigarette sales. But Altria still managed to rake in almost $10 billion in 2007.

In August, the company said it would spin off its Philip Morris International unit, which currently brings in two-thirds of its income, to avoid U.S. lawsuits and allow it to expand in countries such as China, India and Thailand.

NEXT: Pfizer

Last updated April 24 2008: 11:07 AM ET