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17 of 20
17. Wells Fargo
Fortune 500 rank: 41
2007 profit: $8.06 billion

The country's second-biggest mortgage lender weathered a tough market, with profits off only 5% since last year on big losses in home-equity and consumer loans.

Sales rose 12% for the year. In November the company said it would set aside $1.4 billion to cover mortgage losses.

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Last updated April 24 2008: 11:07 AM ET