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4. J.P. Morgan Chase & Co.
Fortune 500 rank: 12
2007 profit: $15.37 billion

A sharp drop in its investment banking business slowed J.P. Morgan's year-over-year profit growth to 6% in 2007 from 70% in 2006.

Although mortgage-related securities losses cut into its bottom line, the Wall Street stalwart was able to dodge the worst of the credit crisis.

NEXT: Bank of America Corp.

Last updated April 24 2008: 11:07 AM ET