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5. Bank of America Corp.
Fortune 500 rank: 9
2007 profit: $14.98 billion

The subprime mortgage fallout and ensuing credit crunch cut into Bank of America's earnings, which fell 29% in 2007 from the year before.

The nation's second-biggest bank - behind Citigroup - also pumped $2 billion into ailing Countrywide Financial (which it said in 2008 it would buy for $4 billion) and bought LaSalle Bank for $21 billion.

NEXT: Microsoft

Last updated April 24 2008: 11:07 AM ET