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6. Microsoft
Fortune 500 rank: 44
2007 profit: $14.07 billion

Microsoft had the highest gross margin of any company on this list, with 28%.

Despite a poor reception for the Vista operating system, both yearly profit and sales increased by double-digit percentages.

Last year, Microsoft also completed its biggest acquisition ever: buying aQuantive, an online-advertising company, for $6 billion.

NEXT: Berkshire Hathaway

Last updated April 24 2008: 11:07 AM ET