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3. Cisco Systems
Fortune 500 rank: 71
Best known as the Internet "plumbing" company that sells routers and switches, Cisco has in recent years built a broader customer base with a diversified suite of products like data storage, set-top cable boxes and video conferencing systems. The company saw its profits soar 31% to $7.3 billion last year.

NEXT: 4. Hewlett-Packard
Last updated April 24 2008: 11:04 AM ET