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5. Intel
Fortune 500 rank: 60
Earnings increased by 38% to $7 billion last year at the world's largest chipmaker, spurred by strong demand for PC processors. But falling prices of flash memory, the type of storage used in devices like the iPod and iPhone, could eat into the company's margins in 2008.

NEXT: 6. Oracle
Last updated April 24 2008: 11:04 AM ET