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5. Oracle
Oracle
Fortune 500 rank: 113

The business software behemoth is enjoying the fruits of its aggressive acquisition strategy, including the 2008 purchase of BEA Systems. Oracle's profits spiked 29.2% to $5.5 billion on a 24.6% increase in sales to $22 billion.

NEXT: Intel
Last updated April 29 2009: 1:31 PM ET
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