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11. Gilead Sciences
Gilead Sciences
Fortune 500 rank: 444
2008 revenue: $5.3 billion
2008 total shareholder return: 11.1%

The No. 2 biotech on the Fortune 500 (after Amgen), Gilead is known for its top-selling HIV drugs, particularly the first single-pill HIV treatment. Its 11% gain in 2008 caps an impressive 5-year run - a return of more than 200%.

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Last updated April 20 2009: 1:34 PM ET
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