10 of 20
10. Hewlett-Packard
Fortune rank: 10
2008 profit: $8.33 Billion
HP continued cutting costs and growing its lead in the PC market in 2008 with hip offerings like its Pavilion series. Profits rose 15% to $8.3 billion as HP passed IBM in sales for the second year.

Led by CEO Mark Hurd, HP acquired IT outsourcing firm Electronic Data Systems for $13 billion and announced it would cut more than 24,000 jobs in the next three years.

NEXT: Pfizer
Last updated April 20 2009: 11:09 AM ET
Top 50 Exxon Mobil pushes Wal-Mart aside to retake the No. 1 slot this year. Which other companies made the top 50 this year? More
They're hiring! As many big companies are announcing mass layoffs, these Fortune 100 employers have at least 150 openings each. More
The biggest losers Companies from AIG to United Airlines, from ConocoPhillips to Motorola lost billions of dollars last year. Who lost the most? More