Fortune rank: 6
2008 profit: $12.94 BillionProfits at the world's biggest health care products maker were driven by sales of over-the-counter brands such as Listerine, Neutrogena and Aveeno.
The drugmaking unit's diversified portfolio covered declines in its prescription drug sales. And 2009 prospects look good. In the Big Pharma group, J&J's portfolio has some of the least exposure to patent losses and generic competition.