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5. Alfred Mann
Alfred Mann
Age: 83
Job title: Founder and CEO, MannKind

The biotech entrepreneur still works 80 hours a week, and just pumped $925 million of his own money into MannKind to keep it out of bankruptcy. The billionaire has started companies in everything from aerospace to biomedicine to solar power. His latest venture: an inhalable form of insulin.

NEXT: Sumner Redstone

Last updated October 24 2009: 8:22 AM ET
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