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10. Johnson & Johnson
Fortune 500 rank: 33
2009 profit: $12.3 billion
CEO Bill Weldon called 2009 one of the hardest years in Johnson & Johnson's 124-year history. The world's biggest health-care products company faced patent expirations worth $3 billion in sales along with a worldwide economic downturn, which drove earnings down.

But by the fourth quarter, sales were rising across all three of its major businesses -- medical devices, pharmaceuticals, and over-the-counter medicines. Meanwhile, JNJ announced 7,500 job cuts that are expected to save up to $900 million in 2010.

NEXT: 11. J.P. Morgan Chase & Co.

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Last updated April 28 2010: 12:41 PM ET
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