4 of 15
4. Alcoa
Jobs lost: 28,000
% drop (1 year): 32%
Remaining employees*: 59,000
Fortune 500 rank: 127

Last year, the New York and Pittsburgh-based aluminum manufacturer sold off a number of its subsidiaries, implemented a global hiring freeze, and laid off thousands of workers, ultimately reducing headcount by a third. In 2007, the company's global workforce was 107,000, almost twice its current size.

NEXT: General Motors

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Last updated May 13 2010: 9:10 AM ET
* Full-time equivalent employees as of the end of 2009
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