Creator, writer, producer, Family Guy
Rank change: Down
Hollywood multitalent MacFarlane hit the road to lambaste Arizona's immigration law and California's gay marriage ban in 2010 but somehow made all his protests hilarious -- a secret of his success. TV's highest-paid writer-producer in history (his $100 million contract with Fox runs through 2012) has three primetime satires: Family Guy, American Dad, and The Cleveland Show. This year Family Guy, already a $1 billion-plus franchise, became the bestselling TV series ever on DVD.
New gig: Universal picked up rights to his $65 million live-action/CGI film about a man and his teddy bear.
NEXT: 29. Dennis Crowley
Last updated October 14 2010: 1:25 PM ET