President, North America Pharmaceuticals GlaxoSmithKline 2010 rank: 27 Age: 51
Overall company profits fell in 2010 amid patent expirations and provisions for ongoing legal disputes. And her unit's revenue shrank to $11.8 billion from $14.3 billion. But sheís
revamped sales and operations, and the company has a robust pipeline.
The list is compiled by FORTUNE editors, who consider four criteria: the size and importance of the womanís business in the global economy, the health and direction of the
business, the arc of the womanís career (resume and runway ahead), and societal and cultural influence.