FORTUNE's annual ranking of America's leading businesswomen


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50. Oprah Winfrey
Oprah Winfrey
Chairman, CEO and Chief Creative Officer, OWN, Chairman, Harpo
OWN
2011 rank: 16
Age: 58
Winfrey remains one of media's most influential women, but she's lost her Midas touch: June newsstand sales of O, the Oprah Magazine fell 17.9%, and OWN, a joint venture between Harpo and Discovery Communications, is struggling. It canceled The Rosie Show in March after low ratings. She'll need to turn OWN around to move back up the list -- and show she can still spin gold.
From the October 8, 2012 issue
How we pick the Power 50
The list is compiled by FORTUNE editors, who consider four criteria: the size and importance of the woman's business in the global economy, the health and direction of the business, the arc of the woman's career (resume and runway ahead), and societal and cultural influence.