6 of 50
6. Oprah Winfrey
Harpo and OWN
2009 rank: 6
Age: 56

After 25 years at the top of daytime TV talk, she's ending her show and launching OWN: the Oprah Winfrey Network on January 1. Her company, Harpo, builds brands like Dr. Phil, Dr. Oz, and Nate Berkus, master of design.

NEXT: Ellen Kullman
Last updated September 30 2010: 2:47 PM ET
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